Protein glycosylation is one of the most important post-translational modifications that regulates a large number of physiological functions, including immunity.
In this regard, antibodies are glycoproteins of the adaptive immune system that play a fundamental role in the identification and neutralization of bacteria, viruses or tumor cells. Each antibody isotype and subclass displays a characteristic glycosylation pattern that modulates its structure and also contributes to its effector and immunogenic functions.
In many diseases, the glycosylation of antibodies can be altered, such as certain autoimmune and infectious diseases, aging and different types of cancer. Our main research interest is to determine the molecular mechanisms of autoimmune diseases mediated by antibody glycosylation applying structural biology, molecular biophysics and biochemistry techniques.
By understanding these mechanisms at the molecular level of detail, we will be better equipped to develop targeted diagnostic and treatment strategies for these diseases.